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Published Nov 24, 22
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Utilization of Cannabidiol (CBD) in Patients with Parkinson's Disease Cannabidiol (CBD) is used as an alternative therapy for the treatment of PD. CBD is a phytoconstituent extracted from Cannabis sativa. Typically, CBD products contain less than 0. 3% of tetrahydrocannabinol to avoid the risk of abuse or dependency. CBD products have been used for neurologic disorders, pain, insomnia, anxiety, headaches, and depression in the USA.

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A clinical trial revealed that administration of 300 mg/d of CBD improved mobility, communication, emotional state, body discomfort, and communication of PD patients compared with placebo treatment. A recent study has also stated that nonmotor symptoms of PD were substantially improved by CBD treatment. Notably, a recent animal model study has reported that CBD exhibited neuroprotective properties in patients with PD by reducing nigrostriatal degeneration and neuroinflammatory responses.

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In addition, CBD treatment decreased the depletion of dopamine, provided anti-inflammatory activity, and slowed oxidative stress in animal models Conclusion Scientists have cautioned against the use of CBD in immunocompromised patients. This is because of the increased risk of weight loss, infection, and anemia. Additionally, owing to the complex pharmacodynamic and pharmacokinetic profile of CBD, it can interact with other drugs easily.

A major advantage of CBD medication, as compared to regular Parkinson's medication, is its lack of time restrictions. There are a number of side effects associated with CBD, including dizziness, confusion, drowsiness, and difficulty concentrating. When taking CBD, it is important to limit or avoid alcohol. If experiencing any side effects, one should stop taking CBD products.

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The use of cannabidiol for therapeutic purposes is new, and further studies need to be conducted on its safety in patients with Parkinson's disease. CBD has been shown to have positive effects in numerous studies, but due to the differences in how the PD brain is built compared with a non-PD brain, separate studies are needed to assure successful results.

et al. (2022) Cannabidiol (CBD) Consideration in Parkinson Disease. The Journal for Nurse Practitioners. , https://www. sciencedirect.com/science/article/pii/S1555415522001398 .

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A recent survey on community perceptions of cannabis use in patients with Parkinson disease (PD) found that patients reported cannabis to be effective at reducing symptom severity. Results also show a lack of knowledge on the different types and administration routes among patients. Researchers said that this is the largest study analyzing the view of patients on cannabis therapy in PD.The study, published in Journal of Parkinson’s Disease, took place in Germany, which in 2017 approved medical cannabis (MC) as a therapy for patients with severe symptoms of PD when other therapies were unsuccessful or not tolerable.



Although many cannabis products and formulations are available to patients, there is a lack of controlled clinical studies addressing MC effectiveness on PD symptoms. It’s also unclear which PD symptoms would be best treated with MC, whether certain cannabis formulations are more effective, or which routes of administration (ROA) patients would prefer most.

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The researchers conducted the nationwide, cross-sectional–based survey by embedding a self-developed questionnaire into an issue of the German Parkinson Association’s journal from March 2019 and by distributing it to select patients who visited their movement disorder outpatient clinic from March 4 to April 21, 2019, to control for report bias.

The questionnaire contained 16 categories and 25 questions, with the latter focusing on subject demographics, patient knowledge about cannabis use in PD, experience with cannabis use, and efficacy and tolerability of cannabis application in users. Of the 24,000 distributed questionnaires, 1126 were returned and 1123 (4. 7%) were included in the analysis.

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In total, 1348 participants were evaluated, with 54. 7% being men, 45. 2% being women, and 0. 1% not answering. Most (83. 3%) were from the nationwide survey and 225 (16. 7%) were from the clinic. The mean (SD) age of all subjects was 71. 6 (8. 9) years, and the mean disease duration was 11.

2) years. Cannabis users made up 15% of participants, of which 13. 9% were regular users, 32. 2% were occasional users, and 42. 6% had tried it once; 11. 4% (23) did not answer. Users were on average 5. 6 (P < . 001) years younger than nonusers. Fifty-four percent reported experiencing a clinical benefit from MC.

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Additionally, 50. 8% of users rated MC as more beneficial than levodopa/dopamine agonists at improving PD symptoms and 23% rated MC to be equal in effectiveness. Pain (43. 9%) and muscle cramps (41. 4%) were the most commonly reported symptoms improved by cannabis use. Overall, relief for 9 motor symptoms, such as akinesia and freezing, and nonmotor symptoms, such as sleep disturbance, depression, anxiety, and restless leg syndrome, were reported by more than 20% of users.